Beautiful gorge - highly recommended. In 2015 I parked at the entrance to Kallikrati gorge, went up to Janina and traversed to Manikas. Description in Erno's link https://www.sfakia-crete-forum.com/read.php?5,1679
is accurate but path between saddle above Kallikrati village and road to Manikas is very vague. Terrain is easy so even when path is lost you should not have problems with traversing this fragment.
I also saw mentioned flock of vultures. Really impressive sight of so many big birds in one place.
Note that path leading down into gorge looks almost impossible to descend and I missed it first time and have to come back 100m because I couldn't believe it is right. Despite appearance in upper part it is in good state and well marked with blue dots and cairns. Situation is worse in middle part. In many places 'stoneslides' destroyed path and you should tread carefully.
Last problems are on approaching Skaloti. It is not official tourist track and locals carefully fenced paths to herd their sheeps/goats. When I was already tired finding my way through this maze was really frustrating. I wouldn't bet I could find the path starting from Skaloti
Returned to Patsianos first by dirt roads above Frangokastello and last part on asphalt.
Big circle took me about 9h.